LAUSR

Abstract The bulbs of Crinum jagus (J. Thomps.) Dandy commonly known as St. Christopher lily or Harmattan lily and locally in Akan as “sukooko” is used in Ghana as a decoction to manage infections, fever, asthma and wounds. The current study seeks to evaluate the anti-infective, antipyretic and anti-inflammatory effects of the aqueous, methanol, ethanol and hexane extracts of Crinum jagus. The High-throughput spot culture growth inhibition (HT-SPOTi) assay, baker's yeast induced pyrexia in rat model and the carrageenan induced foot edema in rats were used to screen for the anti-infective, antipyretic and anti-inflammatory activities of the various extracts of Crinum jagus respectively. The extracts were administered at doses of 30, 150 and 300 mg/kg orally to the rats. Broad-spectrum antimicrobial activity was shown by the methanol extract of Crinum jagus when tested against a panel of microorganisms with MIC values ranging between 1 and 500 mg/L. The activity against Mycobacterium smegmatis, Salmonella typhi and Pseudomonas aeruginosa, which are difficult to eradicate was remarkable. The aqueous extract of Crinum jagus also showed significant anti-inflammatory activity at the lowest dose of 30 mg/kg used in the experiment (p