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STUB1/CHIP is a central component of cellular protein homeostasis and interacts with key proteins involved in the pathogenesis of many neurodegenerative diseases. Missense and truncating mutations in STUB1 lead to… Click to show full abstract
STUB1/CHIP is a central component of cellular protein homeostasis and interacts with key proteins involved in the pathogenesis of many neurodegenerative diseases. Missense and truncating mutations in STUB1 lead to SCAR16. For ideal in vitro disease modelling with isogenic controls, we generated a CHIP knockout cell line from a healthy control with no CHIP functionality, but remaining genomic integrity and verified pluripotency.
Keywords:
line;
homozygous crispr;
generation homozygous;
crispr cas9;
stub1;
cas9 mediated
Journal Title: Stem cell research
Year Published: 2019
Link to full text (if available)
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Journal Title: Stem cell research
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!