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Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi007-A from dermal fibroblasts of an HCM patient with… Click to show full abstract
Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi007-A from dermal fibroblasts of an HCM patient with the p. R663H (c. 1988 G > A) mutation in MYH7. The generated hiPSC line had normal karyotype, showed robust expression of pluripotency markers and could differentiate into all three germ layers in vivo.
Keywords:
mutation myh7;
hypertrophic cardiomyopathy;
hipsc line
Journal Title: Stem cell research
Year Published: 2020
Link to full text (if available)
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Journal Title: Stem cell research
Year Published: 2020
Link to full text (if available)
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recommendations!