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VGLL4 is a new component of the Hippo pathway and bind TEADs to compete with YAP, so as to inhibit tumor progression, but its role in stem cell and organ… Click to show full abstract
VGLL4 is a new component of the Hippo pathway and bind TEADs to compete with YAP, so as to inhibit tumor progression, but its role in stem cell and organ regeneration remains unclear. Using the PiggyBac transposon system, we generated a VGLL4 doxycycline-inducible expression human embryonic stem cell line (WAe001-A-47). The established hESC line retains its normal morphology and pluripotency markers with in vitro differentiation potential, as well as a normal karyotype.
Keywords:
piggybac transposon;
transposon system;
stem cell;
stem;
inducible expression
Journal Title: Stem cell research
Year Published: 2020
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Journal Title: Stem cell research
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!