Photo by cdc from unsplash
The human induced pluripotent stem cell (iPSC) line was constructed from urine cells of a 29 years old male, who attacted by Wilson's disease defected in the ATP7B gene. Two heterozygous… Click to show full abstract
The human induced pluripotent stem cell (iPSC) line was constructed from urine cells of a 29 years old male, who attacted by Wilson's disease defected in the ATP7B gene. Two heterozygous mutations of ATP7B gene were revealed by whole exon sequencing (c.2303C > A and c.3334C > T). The reprogramming factors (OCT-4, SOX-2, KLF4, miR-302-367) were delivered using a non-integrative plasmid. The iPSCs were pluripotency, hereditary stability, and the ability to differentiate into three layers.
Keywords:
wilson disease;
line;
pluripotent stem;
induced pluripotent;
urine cells
Journal Title: Stem cell research
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Stem cell research
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!