odel, cold pressor test, cutaneous electrical and thermal stimulaion and intradermal capsaicin induced hyperalgesia. Pain testing as carried out at baseline, 24, 48, 72 and 144 h after application of… Click to show full abstract
odel, cold pressor test, cutaneous electrical and thermal stimulaion and intradermal capsaicin induced hyperalgesia. Pain testing as carried out at baseline, 24, 48, 72 and 144 h after application of he drugs. Compared to placebo buprenorphine significantly attenated tibial pressure pain (P = 0.007) as well as pressure pain in the VB induced primary hyperalgesic area (P = 0.006). On the other and fentanyl attenuated cold pressor pain compared to placebo P = 0.005). The two drugs were equipotent and better than placebo o thermal pain stimulation (P = 0.0001). They drugs failed to show ignificant analgesic effect to NGF induced muscle soreness, cutaeous electrical stimulation and to capsaicin induced hyperalgesia. n equipotent doses buprenorphine attenuated bone associated ain and primary hyperalgesia more than fentanyl. These tissue nd modality differentiated effects may reflect clinical observations hat opioids act differently.
               
Click one of the above tabs to view related content.