LAUSR

odel, cold pressor test, cutaneous electrical and thermal stimulaion and intradermal capsaicin induced hyperalgesia. Pain testing as carried out at baseline, 24, 48, 72 and 144 h after application of he drugs. Compared to placebo buprenorphine significantly attenated tibial pressure pain (P = 0.007) as well as pressure pain in the VB induced primary hyperalgesic area (P = 0.006). On the other and fentanyl attenuated cold pressor pain compared to placebo P = 0.005). The two drugs were equipotent and better than placebo o thermal pain stimulation (P = 0.0001). They drugs failed to show ignificant analgesic effect to NGF induced muscle soreness, cutaeous electrical stimulation and to capsaicin induced hyperalgesia. n equipotent doses buprenorphine attenuated bone associated ain and primary hyperalgesia more than fentanyl. These tissue nd modality differentiated effects may reflect clinical observations hat opioids act differently.