LAUSR

Kleine-Levin syndrome (KLS) is characterized by recurrent episodes of hypersomnia, cognitive disturbances, apathy, derealization, mooddisturbances, hyperphagia, hypersexuality anddysautonomia [1]. The etiology of KLS is unknown. Increased dopamine turnover in the cerebrospinal fluid (CSF)was shown in one patientwith KLS and was greater in symptomatic than in the asymptomatic period [2]. The dopamine transporter availability decreased in the striatum of a teenager with KLS and was more marked in the symptomatic than in the asymptomatic phase [3]. Serotonin metabolism may have also been altered [4,5]. We therefore investigated dopamine and serotonin metabolism through CSF analysis in six KLS patients (three women), seen during episodes. Four patients were taking psychotropic drugs. CSF samples were collected following a previously reported protocol [6]. Biogenic amines precursors and derived-metabolites, as well as neopterin and total biopterins