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Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how… Click to show full abstract
Somatic mutations in DNMT3A are one of the most prevalent genetic abnormalities found in acute myeloid leukemia (AML) patients. A new study by Guryanova et al. sheds mechanistic insight into how the most common DNMT3A variant protein contributes to AML using a combination of mouse genetics and primary patient samples.
Keywords:
dnmt3a mutations;
dominating negative;
dnmt3a;
negative dnmt3a;
contribute aml;
mutations contribute
Journal Title: Cell stem cell
Year Published: 2017
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Journal Title: Cell stem cell
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!