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Haploinsufficient GATA6 mutations are associated with human pancreatic agenesis. Shi et al. (2017) in this issue of Cell Stem Cell and Tiyaboonchai et al. (2017) in a recent issue of Cell Reports… Click to show full abstract
Haploinsufficient GATA6 mutations are associated with human pancreatic agenesis. Shi et al. (2017) in this issue of Cell Stem Cell and Tiyaboonchai et al. (2017) in a recent issue of Cell Reports utilize hPSCs to characterize GATA6 function during human pancreas development. One functional copy of GATA6 is sufficient for definitive endoderm development and pancreas formation, but it is inadequate for functional β cell differentiation.
Keywords:
got gata;
human pancreas;
pancreas development;
gata human;
cell;
development
Journal Title: Cell stem cell
Year Published: 2017
Link to full text (if available)
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Journal Title: Cell stem cell
Year Published: 2017
Link to full text (if available)
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recommendations!