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Straight to the X: Modeling Human X Chromosome Inactivation in hESCs by FGF Signal Blockade.

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In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive… Click to show full abstract

In this issue of Cell Stem Cell, An et al. (2020) provide a model to study human X chromosome inactivation. They followed X chromosome activity and traced cellular heterogeneity in naive hESCS, showed that it is caused by incomplete blockade of FGF-signaling, and in doing so isolated cells resembling pre-implantation epiblasts.

Keywords: blockade; chromosome inactivation; hescs; human chromosome

Journal Title: Cell stem cell
Year Published: 2020

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