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The depth of quiescence in hematopoietic stem cells (HSCs) dictates their potency and is sensitive to metabolic perturbations. Recent evidence suggests that lysosomal functions distinct from autophagic processes are pivotal… Click to show full abstract
The depth of quiescence in hematopoietic stem cells (HSCs) dictates their potency and is sensitive to metabolic perturbations. Recent evidence suggests that lysosomal functions distinct from autophagic processes are pivotal in regulating quiescence versus activation by potential control of the access to a nutrient reservoir required for HSC activation.
Keywords:
regulation metabolism;
hematopoietic stem;
lysosomal regulation;
stem cells;
metabolism quiescent;
stem
Journal Title: Cell stem cell
Year Published: 2021
Link to full text (if available)
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Journal Title: Cell stem cell
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!