LAUSR

&NA; Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine‐dependent breast cancer. As a member of the nuclear receptor family of ligand‐dependent transcription factors, the main action of PR is to regulate networks of target gene expression in response to binding its cognate steroid hormone, progesterone. Liganded‐PR transcriptional activation has been thoroughly studied and associated mechanisms have been described while progesterone‐mediated repression has remained less explored. The present work summarizes recent advances in the understanding of how PR‐mediated repression is accomplished in breast cancer cells and highlights the significance of fully understanding the determinants of context‐dependent PR action.