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Transmembrane integrin bridges the extracellular and intracellular environments and is activated by focal adhesion proteins, talin and kindlin. Activated integrin engages ligands from the extracellular matrix and controls intracellular responses.… Click to show full abstract
Transmembrane integrin bridges the extracellular and intracellular environments and is activated by focal adhesion proteins, talin and kindlin. Activated integrin engages ligands from the extracellular matrix and controls intracellular responses. In this issue of Structure, Zhu et al. (2019) describe an initial step involving recruitment of paxillin by ubiquitin-like kindlin-2 domain.
Keywords:
outside connection;
kindlin outside;
kindlin
Journal Title: Structure
Year Published: 2019
Link to full text (if available)
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Journal Title: Structure
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!