In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The… Click to show full abstract
In this issue of Structure, Sverzhinsky et al. (2022) report structures of archaeal DNA ligase bound to the proliferating cell nuclear antigen (PCNA) sliding clamp and a nicked DNA substrate. The structures provide snapshots of ligation intermediates, which reveal a dynamic nature of the complex and explain how PCNA stimulates the DNA ligase activity.
Keywords:
dna;
ligase pcna;
pcna double;
dna ligase
Journal Title: Structure
Year Published: 2022
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Journal Title: Structure
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!