LAUSR

Abstract Development of low cost, handheld biosensors for non-invasive disease monitoring is considered to be the future alternative in medical diagnostic technology. In this report, porous NiO nanostructures based electrodes have been fabricated for non-invasive glucose sensing from saliva samples. Nanostructures were grown on fluorine doped tin oxide (FTO) coated glass substrates using chemical bath deposition method. Non-enzymatic glucose sensing with porous NiO electrodes has been investigated at various growth time. The optimized electrode exhibited glucose sensitivity ~ 2632.53 µAmM−1cm−2, within the concentration range ~ 5 µM to 0.825 mM. Our porous electrodes also demonstrated low detection limit (~ 84 nM) along with fast response time. A correlation between salivary and blood glucose level during fasting and after meal has been established with NiO electrodes and commercially available glucometer. Salivary glucose detection using a screen printed electrode was also demonstrated.