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Large heterochromatic domains are found tethered to the lamina. But, is this nuclear environment repressive per se, or just the 'ground state' of inactive chromatin? Elegant studies from the van… Click to show full abstract
Large heterochromatic domains are found tethered to the lamina. But, is this nuclear environment repressive per se, or just the 'ground state' of inactive chromatin? Elegant studies from the van Steensel group (Leemans et al., Cell, 2019) recently demonstrated that the lamina is indeed repressive, but that intrinsic promoter properties also dictate gene activity.
Keywords:
dissecting gene;
location;
gene repression;
repression location;
location location
Journal Title: Trends in cell biology
Year Published: 2019
Link to full text (if available)
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Journal Title: Trends in cell biology
Year Published: 2019
Link to full text (if available)
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recommendations!