A mechanistic description for how soluble protein cargos are sorted into distinct vesicle classes at the level of the trans-Golgi network (TGN) has remained elusive. In a recent study in… Click to show full abstract
A mechanistic description for how soluble protein cargos are sorted into distinct vesicle classes at the level of the trans-Golgi network (TGN) has remained elusive. In a recent study in Developmental Cell, Sundberg et al. reveal that sphingomyelin and a proteoglycan mediate lipoprotein lipase sorting in the TGN.
               
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