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Recent innovations in immunotherapies have cured cancers but remain ineffective in pancreatic cancer, which exhibits intertwined dynamics of dedifferentiation of epithelium and reprogramming ofimmunosuppression. Emerging evidence reveals the biological mechanisms… Click to show full abstract
Recent innovations in immunotherapies have cured cancers but remain ineffective in pancreatic cancer, which exhibits intertwined dynamics of dedifferentiation of epithelium and reprogramming ofimmunosuppression. Emerging evidence reveals the biological mechanisms through which dedifferentiation recapitulates immune reprogramming, providing new insights into the therapeutic potential of controlling dedifferentiation for sensitization to immunotherapies.
Keywords:
epithelial cells;
immune reprogramming;
cells incorporates;
incorporates immune;
dedifferentiation;
dedifferentiation epithelial
Journal Title: Trends in cell biology
Year Published: 2021
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Journal Title: Trends in cell biology
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!