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Synthesis of 3-oxadiazolyl/triazolyl morpholines: Novel scaffolds for drug discovery

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Abstract Synthesis of isomeric 3-oxadiazolyl/triazolyl morpholines was performed based on a common intermediate on the gram scale. The target compounds were designed as novel scaffolds for the medicinal chemistry. The… Click to show full abstract

Abstract Synthesis of isomeric 3-oxadiazolyl/triazolyl morpholines was performed based on a common intermediate on the gram scale. The target compounds were designed as novel scaffolds for the medicinal chemistry. The key reaction was an electrochemical CH-oxidation of N-Boc morpholine.

Keywords: novel scaffolds; triazolyl morpholines; synthesis; oxadiazolyl triazolyl

Journal Title: Tetrahedron
Year Published: 2017

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