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Abstract This paper describes our efforts towards the asymmetric total synthesis of (+)-actinophyllic acid. Starting from the chiral oxazolidinone 9 , an azocino [4,3- b ]indolyl intermediate ( 5 )… Click to show full abstract
Abstract This paper describes our efforts towards the asymmetric total synthesis of (+)-actinophyllic acid. Starting from the chiral oxazolidinone 9 , an azocino [4,3- b ]indolyl intermediate ( 5 ) possessing the A/B/C ring system and the C16 quaternary stereogenic center of actinophyllic acid has been synthesized. Key steps include a LHMDS-promoted condensation to establish the critical C2–C16 bond and a successive four-step transformation to assemble the eight-membered C-ring of the target molecule.
Keywords:
approach towards;
towards total;
asymmetric approach;
total synthesis;
acid;
synthesis
Journal Title: Tetrahedron
Year Published: 2017
Link to full text (if available)
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Journal Title: Tetrahedron
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!