Photo by conscious_design from unsplash
A bstract A highly convergent total synthesis of (+)-methynolide, based on two types of stereoselective aldol reaction, was achieved. The C1-C8 and C9-C11 fragments of (+)-methynolide were prepared by a… Click to show full abstract
A bstract A highly convergent total synthesis of (+)-methynolide, based on two types of stereoselective aldol reaction, was achieved. The C1-C8 and C9-C11 fragments of (+)-methynolide were prepared by a vinylogous Mukaiyama aldol reaction using a vinyl ketene silyl N,O-acetal, and a Ti-mediated aldol reaction of a lactyl-bearing chiral oxazolidin-2-one, respectively. Yamaguchi esterification of both fragments and ring-closing metathesis afforded (+)-methynolide.
Keywords:
aldol reaction;
synthesis methynolide;
total synthesis;
reaction;
vinylogous mukaiyama;
mukaiyama aldol
Journal Title: Tetrahedron
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!
Journal Title: Tetrahedron
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!