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Abstract New 2-substituted pyrazolo[5,1- b ][1,3]oxazoles are synthesized through the Sonogashira coupling reaction of 2-iodomethyl-6-methylpyrazolo[5,1- b ][1,3]oxazole with terminal alkynes in the presence of a palladium catalyst. This process is… Click to show full abstract
Abstract New 2-substituted pyrazolo[5,1- b ][1,3]oxazoles are synthesized through the Sonogashira coupling reaction of 2-iodomethyl-6-methylpyrazolo[5,1- b ][1,3]oxazole with terminal alkynes in the presence of a palladium catalyst. This process is carried out in the absence of any copper salt, and provides an eco-friendly and efficient method for the synthesis of the products in water in good-to-high yields. Some of the compounds synthesized were screened for their in vitro anti-oxidant activity using the DPPH (2,2-diphenyl-2-picrylhydrazyl) assays.
Journal Title: Tetrahedron
Year Published: 2017
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