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A synthesis of tiruchanduramine and a reinvestigation of its glycosidase inhibitory activity

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Abstract Tiruchanduramine 1 was prepared using a convergent strategy with the longest linear sequence being eight steps. Synthetic 1, displayed a broader range of inhibition than reported previously and, in… Click to show full abstract

Abstract Tiruchanduramine 1 was prepared using a convergent strategy with the longest linear sequence being eight steps. Synthetic 1, displayed a broader range of inhibition than reported previously and, in addition to α-glucosidases, 1 also inhibits almond β-glucosidase, β-galactosidase and β-N-acetylglucosaminidase from jack bean.

Keywords: tiruchanduramine; glycosidase inhibitory; synthesis tiruchanduramine; tiruchanduramine reinvestigation; reinvestigation glycosidase; inhibitory activity

Journal Title: Tetrahedron
Year Published: 2017

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