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An efficient one-pot protocol for the solvent-free synthesis of novel quinoline-3-thiocarboxamide and 2,3-dihydroquinazolin-4(1 H )-one derivatives

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Abstract An efficient and straightforward synthesis of a series of novel poly-substituted quinoline-3-thiocarboxamides 3 and 2-(2-oxo-2-arylethylidene)-2,3-dihydroquinazolin-4(1H)-ones 4 from 3-oxo-N,3-diarylpropanethioamide 1 and the respective 2-aminoarylketone/2-aminoarylcarboxylic acid ester 2 by a two-component… Click to show full abstract

Abstract An efficient and straightforward synthesis of a series of novel poly-substituted quinoline-3-thiocarboxamides 3 and 2-(2-oxo-2-arylethylidene)-2,3-dihydroquinazolin-4(1H)-ones 4 from 3-oxo-N,3-diarylpropanethioamide 1 and the respective 2-aminoarylketone/2-aminoarylcarboxylic acid ester 2 by a two-component solvent-free reaction protocol was described.

Keywords: efficient one; protocol; quinoline; solvent free; synthesis; dihydroquinazolin

Journal Title: Tetrahedron
Year Published: 2017

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