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Abstract An efficient, one-pot, two-step, four-component reaction for the synthesis of spiroindoloquinazoline derivatives in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) is described. The syntheses are achieved by the condensation reaction of… Click to show full abstract
Abstract An efficient, one-pot, two-step, four-component reaction for the synthesis of spiroindoloquinazoline derivatives in the presence of 1,4-diazabicyclo[2.2.2]octane (DABCO) is described. The syntheses are achieved by the condensation reaction of isatin derivatives, isatoic anhydride, malononitrile and carbonyl compounds under reflux in acetonitrile. Several of the resulting compounds showed moderate activity as phospholipase A2 inhibitors.
Keywords:
four component;
synthesis spiroindoloquinazoline;
spiroindoloquinazoline derivatives;
phospholipase inhibitors;
one pot
Journal Title: Tetrahedron
Year Published: 2017
Link to full text (if available)
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Journal Title: Tetrahedron
Year Published: 2017
Link to full text (if available)
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recommendations!