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Abstract A continuous-flow synthesis of primary amides from hydrolysis of nitriles using hydrogen peroxide as oxidant has been developed. Using this procedure, a variety of nitriles could be smoothly transformed… Click to show full abstract
Abstract A continuous-flow synthesis of primary amides from hydrolysis of nitriles using hydrogen peroxide as oxidant has been developed. Using this procedure, a variety of nitriles could be smoothly transformed into the desired primary amides in good to excellent yields. The mild reaction conditions and the flowing reaction system greatly improved the safety and make the reaction easy to scale up.
Keywords:
amides hydrolysis;
flow synthesis;
synthesis primary;
hydrolysis nitriles;
continuous flow;
primary amides
Journal Title: Tetrahedron
Year Published: 2018
Link to full text (if available)
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Journal Title: Tetrahedron
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!