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Inline, real time NMR and temperature measurements have been used to optimise the continuous flow synthesis of difluoromethyltrimethylsilane (TMSCF2H) by the reduction of the Ruppert-Prakash reagent (TMSCF3). These measurements were… Click to show full abstract
Inline, real time NMR and temperature measurements have been used to optimise the continuous flow synthesis of difluoromethyltrimethylsilane (TMSCF2H) by the reduction of the Ruppert-Prakash reagent (TMSCF3). These measurements were used to maximise the space-time-yield, while ensuring this exothermic process remains safe. In this way, a three-fold increase in space-time-yield was achieved compared to the reported batch procedure, isolating 25 g of pure TMSCF2H after 105 min.
Keywords:
nmr temperature;
flow batch;
continuous flow;
synthesis;
batch hybrid
Journal Title: Tetrahedron
Year Published: 2018
Link to full text (if available)
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Journal Title: Tetrahedron
Year Published: 2018
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!