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Abstract An improved synthesis of pennogenin, a bioactive component of Chinese herb “Chonglou” (Paris), is described. A ring-switching process opened the ring E of diosgenin and allowed the use of… Click to show full abstract
Abstract An improved synthesis of pennogenin, a bioactive component of Chinese herb “Chonglou” (Paris), is described. A ring-switching process opened the ring E of diosgenin and allowed the use of a hydroxyl-directed diboration/oxidation to introduce C17α-OH, hence eliminating the use of OsO4. This strategy might be rendered to synthesize similar steroids with C17α-OH.
Keywords:
synthesis pennogenin;
improved synthesis
Journal Title: Tetrahedron
Year Published: 2019
Link to full text (if available)
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Journal Title: Tetrahedron
Year Published: 2019
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!