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Copper-catalyzed decarboxylation/cycloaddition cascade of alkynyl carboxylic acids with azide

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Abstract A copper-catalyzed decarboxylation/cycloaddition cascade of alkynyl carboxylic acids with azide has been developed. This reaction exhibits good functional group tolerance and wide substrate scope, provides an efficient way to… Click to show full abstract

Abstract A copper-catalyzed decarboxylation/cycloaddition cascade of alkynyl carboxylic acids with azide has been developed. This reaction exhibits good functional group tolerance and wide substrate scope, provides an efficient way to construct 1,4-disubstituted 1,2,3-triazoles.

Keywords: cascade alkynyl; alkynyl carboxylic; decarboxylation cycloaddition; catalyzed decarboxylation; cycloaddition cascade; copper catalyzed

Journal Title: Tetrahedron
Year Published: 2019

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