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Recent applications of magnesium- and Zinc-TMP amides in the synthesis of bioactive targets

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Abstract Magnesium- and zinc-TMP amides have come out from relative obscurity to be recognized as important tools in modern synthetic chemistry. Development of LiCl-activated metal amides like TMPMgCl·LiCl and TMP2Zn·2MgCl2·2LiCl… Click to show full abstract

Abstract Magnesium- and zinc-TMP amides have come out from relative obscurity to be recognized as important tools in modern synthetic chemistry. Development of LiCl-activated metal amides like TMPMgCl·LiCl and TMP2Zn·2MgCl2·2LiCl has been important to obtain new organometallic reagents through highly chemo- and regioselective reactions. Herein, we review how these reagents are applied in the synthesis of important bioactive targets such as natural products and drugs.

Keywords: zinc tmp; tmp amides; magnesium zinc; bioactive targets

Journal Title: Tetrahedron
Year Published: 2019

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