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Abstract A general approach to prepare unsymmetrical sulfamides is described. This method relies on the activation of sulfamic acid salts with triphenylphosphine ditriflate, and subsequent trapping by a nucleophilic amine.… Click to show full abstract
Abstract A general approach to prepare unsymmetrical sulfamides is described. This method relies on the activation of sulfamic acid salts with triphenylphosphine ditriflate, and subsequent trapping by a nucleophilic amine. This strategy improves access to N-octadecyl-N′-propylsulfamide, a feeding suppressant.
Keywords:
efficient synthesis;
unsymmetrical sulfamides;
acid salts;
sulfamic acid;
triphenylphosphine ditriflate
Journal Title: Tetrahedron
Year Published: 2019
Link to full text (if available)
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Journal Title: Tetrahedron
Year Published: 2019
Link to full text (if available)
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recommendations!