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Photoredox-catalyzed deoxyfluorination of activated alcohols with Selectfluor®.

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Herein we disclose a deoxyfluorination of alcohols with an electrophilic fluorine source via visible-light photoredox catalysis. This radical-mediated C-F coupling is capable of fluorinating secondary and tertiary alcohols efficiently, complementing… Click to show full abstract

Herein we disclose a deoxyfluorination of alcohols with an electrophilic fluorine source via visible-light photoredox catalysis. This radical-mediated C-F coupling is capable of fluorinating secondary and tertiary alcohols efficiently, complementing previously reported nucleophilic deoxyfluorination protocols.

Keywords: deoxyfluorination; alcohols selectfluor; catalyzed deoxyfluorination; deoxyfluorination activated; photoredox catalyzed; activated alcohols

Journal Title: Tetrahedron
Year Published: 2019

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