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Abstract A novel asymmetric synthetic strategy to prepare 4-aryl-dihydroisoquinolinones has been developed through a highly regioselective Friedel-Crafts alkylation of benzylamine derivatives with (αR)-α-bromo arylacetates and subsequent facile lactamization. In addition,… Click to show full abstract
Abstract A novel asymmetric synthetic strategy to prepare 4-aryl-dihydroisoquinolinones has been developed through a highly regioselective Friedel-Crafts alkylation of benzylamine derivatives with (αR)-α-bromo arylacetates and subsequent facile lactamization. In addition, an efficient asymmetric synthesis of 2-aryl morpholinones is demonstrated with 2-aminoethanol derivatives using the same convenient substitution-lactamization protocol.
Keywords:
dihydroisoquinolin ones;
synthesis aryl;
aryl dihydroisoquinolin;
asymmetric synthesis
Journal Title: Tetrahedron
Year Published: 2020
Link to full text (if available)
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Journal Title: Tetrahedron
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!