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Hypoxia-activated pro-drugs of the KDAC inhibitor vorinostat (SAHA)

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Abstract Hypoxia (lower than normal oxygen) is a characteristic of most solid tumours that results in poor cancer patient prognosis. The difference in cellular environment between normoxia (21% oxygen) or… Click to show full abstract

Abstract Hypoxia (lower than normal oxygen) is a characteristic of most solid tumours that results in poor cancer patient prognosis. The difference in cellular environment between normoxia (21% oxygen) or physoxia (4–7.5% oxygen) and hypoxia (

Keywords: hypoxia; pro drugs; kdac inhibitor; hypoxia activated; activated pro; drugs kdac

Journal Title: Tetrahedron
Year Published: 2020

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