Photo by milada_vigerova from unsplash
Abstract Bicyclo[1.1.1]pentane is widely recognized as the bioisostere for aryl, tert-butyl, and internal alkynes. Herein we report an efficient and practical method for the preparation of selenoether and thioether functionalized… Click to show full abstract
Abstract Bicyclo[1.1.1]pentane is widely recognized as the bioisostere for aryl, tert-butyl, and internal alkynes. Herein we report an efficient and practical method for the preparation of selenoether and thioether functionalized bicyclo[1.1.1]pentanes from selenosulfonates/thiosulfonates and propellane. A variety of valuable bicyclo[1.1.1]pentanes bearing both selenoether/thioether and sulfone are obtained under mild conditions with good yields. The protocol features broad functional group compatibility, excellent atom-economy, simple operation, and gram-scale preparation.
Journal Title: Tetrahedron
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!