LAUSR

Abstract We present the synthesis, using combinatorial chemistry methodology, of a series of 11 selective anion receptors with special affinity for carboxylates. These compounds contain a urea function and their macrocyclic platform has the structure of previously reported “Unclosed Cryptand”. The use, at the stage of postfunctionalisation of the lariat arm, of properly selected templates allows for non-statistical synthesis of the expected products, whose concentration in the reaction mixture depends on the geometrical factors of the substrates used and their electronic properties. Postfunctionalization of the said arm, after the yield limiting macrocyclization reaction, makes it possible to influence the selectivity of complexing the guest molecules introduced into the system.