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ABSTRACT Here we report a one-pot synthesis of multisubstituted spiroindolenines from a series of tryptamine derivatives with γ-chloro-α,β-unsaturated ketones. The reaction sequence consists of base-induced condensation and silica gel-promoted intramolecular… Click to show full abstract
ABSTRACT Here we report a one-pot synthesis of multisubstituted spiroindolenines from a series of tryptamine derivatives with γ-chloro-α,β-unsaturated ketones. The reaction sequence consists of base-induced condensation and silica gel-promoted intramolecular Michael addition. The target molecules are afforded in up to 90% yield with up to >20:1 diastereoselectivity.
Keywords:
unsaturated ketones;
synthesis multisubstituted;
multisubstituted spiroindolenines;
chloro unsaturated;
silica gel;
gel promoted
Journal Title: Tetrahedron
Year Published: 2021
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Journal Title: Tetrahedron
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!