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Abstract Enantioselective C(sp2)−H borylations of diarylmethylsilanes were catalyzed using iridium complexes with chiral pyridine-dihydroisoquinoline (PyDHIQ) ligands. High enantioselectivities (up to >99% ee) were observed for various substrates. A gram-scale synthesis… Click to show full abstract
Abstract Enantioselective C(sp2)−H borylations of diarylmethylsilanes were catalyzed using iridium complexes with chiral pyridine-dihydroisoquinoline (PyDHIQ) ligands. High enantioselectivities (up to >99% ee) were observed for various substrates. A gram-scale synthesis was achieved using 1 mol% of the catalyst to afford a 91% yield of the desired chiral borylated organosilane product with > 99% ee.
Keywords:
chiral pyridine;
pyridine dihydroisoquinoline;
iridium complexes;
enantioselective sp2;
diarylmethylsilanes catalyzed
Journal Title: Tetrahedron
Year Published: 2020
Link to full text (if available)
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Journal Title: Tetrahedron
Year Published: 2020
Link to full text (if available)
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recommendations!