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Nano-CuO catalyzed one-pot C–H azidation/azide-alkyne cycloaddition for triazole-substituted 8-aminoquinolines

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Abstract One-pot C-H azidation/azide-alkyne cycloaddition of 8-aminoquinoline at C-5 position is achieved with Nano-CuO. Variety of different substrates have been found compatible and gave the corresponding products from moderate to… Click to show full abstract

Abstract One-pot C-H azidation/azide-alkyne cycloaddition of 8-aminoquinoline at C-5 position is achieved with Nano-CuO. Variety of different substrates have been found compatible and gave the corresponding products from moderate to good yields. This strategy provides a practical method for the synthesis of triazole-substituted 8-aminoquinolines with one-pot, Nano-CuO-catalyst, mild reaction conditions and high step economy.

Keywords: azide alkyne; nano cuo; pot azidation; azidation azide; one pot

Journal Title: Tetrahedron
Year Published: 2021

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