Abstract Four new ent-cleistanthane type diterpenoids, phyacioids A–D (1–4), along with two known analogues (5 and 6) were isolated from the powered twigs and leaves of Phyllanthus acidus. Compound 1… Click to show full abstract
Abstract Four new ent-cleistanthane type diterpenoids, phyacioids A–D (1–4), along with two known analogues (5 and 6) were isolated from the powered twigs and leaves of Phyllanthus acidus. Compound 1 was characterized as the third reported structure that possesses a 4,5-seco-20(10 → 5)-abeo-(ent)-cleistanthane scaffold, and compounds 2 and 3 feature a rare alkynyl group. The structures of 1–4 were assigned by spectroscopic data, with their absolute structures being determined through electric circular dichroism (ECD) calculations. Compounds 3, 5 and 6 showed moderate cytotoxicity with IC50 values ranging from 13.8 to 36.0 μM.
               
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