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Abstract A Pd(II)-catalyzed acetoxylation of 2H-indazoles with phenyliodine (III) diacetate (PIDA) has been successfully developed. Notably, pharmacophore 2H-indazole was utilized as an inherent directing group to access ortho-acetoxylated arylindazoles in… Click to show full abstract
Abstract A Pd(II)-catalyzed acetoxylation of 2H-indazoles with phenyliodine (III) diacetate (PIDA) has been successfully developed. Notably, pharmacophore 2H-indazole was utilized as an inherent directing group to access ortho-acetoxylated arylindazoles in moderate to high yields. The representative acetoxylated indazole could further undergo hydrolysis to afford the corresponding hydroxylated product.
Keywords:
acetoxylation arylindazoles;
acetoxylation;
palladium catalyzed;
catalyzed acetoxylation
Journal Title: Tetrahedron
Year Published: 2021
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Journal Title: Tetrahedron
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!