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Abstract A decarboxylative coupling reaction with an alkynyl carboxylic acid and aryl iodides in the presence of a nickel catalyst was developed. When the reaction was conducted with NiCl 2… Click to show full abstract
Abstract A decarboxylative coupling reaction with an alkynyl carboxylic acid and aryl iodides in the presence of a nickel catalyst was developed. When the reaction was conducted with NiCl 2 (10 mol%), Xantphos (15 mol%), Mn (1.0 equiv), and Cs 2 CO 3 (1.5 equiv), the desired diaryl alkynes were formed in moderated to good yields. Furthermore, this method does not produce the diyne, which is formed in the homocoupling of alkynyl carboxylic acids.
Keywords:
acid aryl;
aryl iodides;
carboxylic acid;
decarboxylative coupling;
alkynyl carboxylic
Journal Title: Tetrahedron Letters
Year Published: 2017
Link to full text (if available)
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Journal Title: Tetrahedron Letters
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!