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Synthesis and identification of an important metabolite of AKB-48 with a secondary hydroxyl group on the adamantyl ring

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Abstract Studies on the metabolism of bioactive substances containing the adamantyl moiety have shown that hydroxylation is likely to occur at a tertiary carbon of adamantane. Herein, we report the… Click to show full abstract

Abstract Studies on the metabolism of bioactive substances containing the adamantyl moiety have shown that hydroxylation is likely to occur at a tertiary carbon of adamantane. Herein, we report the synthesis and identification of one major metabolite of AKB-48, a new illicit psychoactive substance with a hydroxyl group at a secondary carbon of the adamantyl ring.

Keywords: synthesis identification; hydroxyl group; adamantyl ring; metabolite akb

Journal Title: Tetrahedron Letters
Year Published: 2017

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