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Abstract Two acridones, paratrimerins C ( 1 ) and D ( 2 ), and two coumarins, paratrimerins E ( 3 ) and F ( 4 ), were isolated from the… Click to show full abstract
Abstract Two acridones, paratrimerins C ( 1 ) and D ( 2 ), and two coumarins, paratrimerins E ( 3 ) and F ( 4 ), were isolated from the CHCl 3 and EtOAc extracts of Paramignya trimera (Rutaceae), together with twelve known compounds ( 5 – 16 ). Their structures were elucidated on the basis of spectroscopic data. All isolated compounds possessed significant α -glucosidase inhibitory activity in a concentration-dependent manner, and showed more potent inhibitory activity, with IC 50 values ranging from 14.6 to 112.2 μM, than the positive control acarbose (IC 50 , 214.5 μM). The biosynthesis of the isolated coumarins and acridones was proposed.
Journal Title: Tetrahedron Letters
Year Published: 2017
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