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Abstract Three 24-methyl-lanostane triterpenoids, fomitopsins D–F ( 1 – 3 ), were isolated together with four known compounds ( 4 – 7 ) from fruiting bodies of the basidiomycete Fomitopsis… Click to show full abstract
Abstract Three 24-methyl-lanostane triterpenoids, fomitopsins D–F ( 1 – 3 ), were isolated together with four known compounds ( 4 – 7 ) from fruiting bodies of the basidiomycete Fomitopsis feei . The structures were elucidated by spectroscopic analysis and chemical correlations, including the conversion of 1 into a mixture of 2 and 3 under acidic conditions. Compound 1 was previously isolated after conversion to a methyl ester derivative, however, the side-chain stereochemistry was not determined. Fomitopsins E ( 2 ) and F ( 3 ) exhibited activity against Bacillus cereus with MIC values of 6.25 μg/mL. On the other hand, fomitopsin D ( 1 ) showed activity against herpes simplex virus type 1 (HSV-1) with an IC 50 value of 17 μg/mL.
Journal Title: Tetrahedron Letters
Year Published: 2017
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