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Abstract The first metal-catalyzed oxidative intermolecular 1,4-diamination of conjugated dienes has been developed. A series of medium ring compounds were constructed via palladium-catalyzed intermolecular [4+4] annulations. Oxygen was successfully used… Click to show full abstract
Abstract The first metal-catalyzed oxidative intermolecular 1,4-diamination of conjugated dienes has been developed. A series of medium ring compounds were constructed via palladium-catalyzed intermolecular [4+4] annulations. Oxygen was successfully used as an oxidant instead of the existing stoichiometric metals or hypervalent iodine reagents. 20 examples are reported, and good yields and regioselectivities could be obtained for the majority of diamines and conjugated diene substrates.
Journal Title: Tetrahedron Letters
Year Published: 2017
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