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Abstract Tin reduction of 3,4,4,5-tetrachloro-4 H -1,2,6-thiadiazine afforded perchloro-9-thia-1,5,8,10-tetraazaspiro[5.5]undeca-1,4,7,10-tetraene (10%) and 3,5-dichloro-4 H -1,2,6-thiadiazine-4-thione (27%), the structures of which were supported by single crystal X-ray crystallography. Treating the tetrachlorothiadiazine with… Click to show full abstract
Abstract Tin reduction of 3,4,4,5-tetrachloro-4 H -1,2,6-thiadiazine afforded perchloro-9-thia-1,5,8,10-tetraazaspiro[5.5]undeca-1,4,7,10-tetraene (10%) and 3,5-dichloro-4 H -1,2,6-thiadiazine-4-thione (27%), the structures of which were supported by single crystal X-ray crystallography. Treating the tetrachlorothiadiazine with Ph 3 P (1 equiv.) afforded the corresponding spirocycle in a useful 66% yield, the degradation of which with BnEt 3 NCl (0.5 equiv.) afforded densely functionalized 4,5,6-trichloropyrimidine-2-carbonitrile in 81% yield. Rational mechanisms for the formation of products are proposed.
Journal Title: Tetrahedron Letters
Year Published: 2017
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