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A simple and highly efficient copper iodide catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones have been developed from anthranilamide, terminal alkynes and azides. A wide variety of alkynes were screened to… Click to show full abstract
A simple and highly efficient copper iodide catalyzed one-pot synthesis of 2-substituted quinazolin-4(3H)-ones have been developed from anthranilamide, terminal alkynes and azides. A wide variety of alkynes were screened to understand the scope of this methodology. This method has been extended for the synthesis of 5-substituted pyrazolo[4,3-d]pyrimidin-7(6H)-ones which are having potential applications in medicinal chemistry.
Keywords:
substituted quinazolin;
pot synthesis;
synthesis substituted;
copper iodide;
one pot;
synthesis
Journal Title: Tetrahedron Letters
Year Published: 2017
Link to full text (if available)
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Journal Title: Tetrahedron Letters
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!