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The preparation and cycloaddition reaction of 1-sulfonyl-1-trifluoromethyl allenes

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A series of 1-sulfonyl-1-trifluoromethyl allenes were prepared for the first time from commercial available 2-bromo-3,3,3-trifluoropropene. Cycloaddition reaction of these trifluoromethylated allenes with nitrones occured readily under mild conditions, giving the… Click to show full abstract

A series of 1-sulfonyl-1-trifluoromethyl allenes were prepared for the first time from commercial available 2-bromo-3,3,3-trifluoropropene. Cycloaddition reaction of these trifluoromethylated allenes with nitrones occured readily under mild conditions, giving the corresponding trifluoromethylated isoxazolidines in high yields.

Keywords: sulfonyl trifluoromethyl; cycloaddition reaction; trifluoromethyl allenes

Journal Title: Tetrahedron Letters
Year Published: 2017

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