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Thermally induced reaction of diazoamides with isatins: A complementary approach to the 3,3′-bioxindole derivatives

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Abstract An efficient and thermally induced reaction of diazoamide with isatin under mild reaction conditions is described, which provides a complementary approach to the 3,3′-bioxindole in high yields with excellent… Click to show full abstract

Abstract An efficient and thermally induced reaction of diazoamide with isatin under mild reaction conditions is described, which provides a complementary approach to the 3,3′-bioxindole in high yields with excellent diastereoselectivity. In comparison to the metal-catalyzed versions, this is the only example under catalyst-free conditions via a non-carbene reaction pathway.

Keywords: induced reaction; approach bioxindole; thermally induced; complementary approach; reaction

Journal Title: Tetrahedron Letters
Year Published: 2017

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